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Ewing Sarcoma
Aggressive malignant tumour of bone or soft tissue, primarily affecting children and young adults.
Ewing sarcoma is a small, round blue cell tumour typically arising in the diaphysis of long bones, pelvis, or ribs. It is characterised by a specific chromosomal translocation t(11;22)(q24;q12), resulting in the EWS-FLI1 fusion gene.
Clinical presentation includes localised pain, swelling, and sometimes systemic symptoms such as fever.
Diagnosis involves MRI, CT chest, bone scan/PET, and biopsy with cytogenetic analysis.
Treatment consists of multi-agent chemotherapy, surgical resection, and/or radiotherapy. Prognosis depends on tumour size, site, metastatic status, and response to initial therapy.
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