Primary Bone Lymphoma
A rare lymphoma subtype presenting primarily in bone, often mimicking other primary bone tumours.
Main Text:
Primary bone lymphoma (PBL) is a rare form of extranodal non-Hodgkin lymphoma that originates in the bone without initial lymph node involvement.
The most common histological subtype is diffuse large B-cell lymphoma (DLBCL).
PBL frequently involves long bones like the femur, pelvis, or spine and typically presents with pain, swelling, or a pathologic fracture.
Radiographically, it may appear as a lytic or permeative lesion with periosteal reaction, mimicking Ewing sarcoma or osteomyelitis.
Diagnosis is confirmed via biopsy and immunohistochemistry (e.g., CD20+, BCL6+, MUM1+ in DLBCL).
Treatment includes systemic chemotherapy (usually R-CHOP regimen) and often radiotherapy.
Surgical intervention is limited to stabilization of fractures or biopsy.
Prognosis is generally favourable compared to other primary bone malignancies, especially with early diagnosis and treatment.
