Soft Tissue Tumor Classification
The WHO introduced the classification of soft tissue and bone tumors (fifth edition) in 2020.
The new WHO classification of soft tissue and bone tumors, introduced in 2020 (fifth edition), has made significant improvements in classification and introduced many new diagnoses.
Soft Tissue Tumor Classification
Group | Benign | Intermediate (Local Agressive) | Malignant |
Adipocytic | Lipoma, Lipomatosis, Angiolipoma, Hibernoma vb. | Atypical lipomatous tumor | Well-diff. liposarcoma, Dediff. liposarcoma, Myxoid liposarcoma vb. |
Fibroblastic / Myofibroblastic | Nodular fasciitis, Elastofibroma, Fibroma of tendon sheath vb. | Palmar/Plantar fibromatosis, Desmoid-type fibromatosis, Dermatofibrosarcoma protuberans vb. | Fibrosarcoma NOS, Myxofibrosarcoma, Sclerosing epithelioid fibrosarcoma vb. |
Fibrohistiocytic | Tenosynovial giant cell tumor | Plexiform fibrohistiocytic tumor, Giant cell tumor of soft parts | Malignant tenosynovial giant cell tumor |
Vascular | Synovial hemangioma, Epithelioid hemangioma, Lymphangioma vb. | Kaposiform hemangioendothelioma, Retiform hemangioendothelioma, Kaposi sarcoma vb. | Epithelioid hemangioendothelioma, Angiosarcoma |
Pericytic | Glomus tumor NOS, Myopericytoma, Angioleiomyoma | — | Malignant glomus tumor |
Skeletal muscle | Rhabdomyoma | — | Rhabdomyosarcoma (Embryonal, Alveolar, Pleomorphic, Spindle cell vb.) |
Chondro-osseous | Chondroma | — | Extraskeletal osteosarcoma |
Peripheral nerve sheath | Schwannoma, Neurofibroma, Perineurioma, Granular cell tumor vb. | — | Malignant peripheral nerve sheath tumor, Melanotic variant vb. |
Uncertain differentiation | Myxoma, Angiomyolipoma vb. | Haemosiderotic fibrolipomatous tumor, Atypical fibroxanthoma vb. | Synovial sarcoma, Epithelioid sarcoma, Clear cell sarcoma, Undifferentiated sarcomas vb. |
Undifferentiated small round cell | — | — | Ewing sarcoma, CIC-rearranged sarcoma, Sarcoma with BCOR alterations |