Deep Peroneal Nerve (DPN) Entrapment

M.D. Alparslan Uzun· Istanbul Medipol University, School of Medicine, Department of Orthopedics and Traumatology
Apr 25, 2026

Definition

·      Rare compression neuropathy affecting deep peroneal nerve

·      Mostly at the fibroosseous tunnel formed by inferior extensor retinaculum

·      Also called “Anterior Tarsal Tunnel Syndrome”

Pathoanatomy

·      DPN travels with anterior tibial artery in the interval between EDL and EHL

·      Just proximal to the ankle, it bifurcates into lateral and medial branches

o   Lateral branch innervates extensor digitorum brevis

o   Medial branch supplies sensation from first dorsal web space

·      Entrapment under superior and inferior extensor retinacula can cause symptoms

·      Compression under inferior extensor retinaculum is known as “Anterior TTS”

·      Intrinsic Impingement

o   Dorsal osteophytes over tibiotalar and talonavicular joints

o   Ganglion cysts

o   Tumor

o   Peripheral edema

o   Enlarged muscle belly of EHL, EDL, EDB

·      Extrinsic Impingement

o   Tight shoes

o   High heels

o   Trauma (ankle inversion and plantar flexion)

·      Associated conditions: pes cavus, navicular nonunion, talonavicular arthritis

 

Evaluation

·      Burning pain on the dorsum of the foot with first dorsal web space paresthesia

·      Usually exacerbated by activities and relieved by rest

·      Nocturnal pain is common due to plantar flexion cause the nerve stretch

·      High heel shoes also reproduce these symptoms by the same reason

·      Weakness/atrophy of EDB, first dorsal web space paresthesia and positive Tinel sign

·      Symptoms relieve with the injection of lidocaine (DPN nerve block)

Imaging

·      X-Rays show dorsal osteophytes and previous fracture sequalea

·      CT can detect bony anatomy of the canal

·      MRI is the best way to see masses

·      Electrodiagnostic studies are usually normal, but may show a delay in latency or denervation of EDB

Treatment

·      Non-surgical

o   Reducing the pressure by avoiding tight fitting shoes and high heels

o   Diuretics can be used in chronic edema, NSAIDs

o   Corticosteroid and local anesthetic injection helps confirming the diagnosis

·      Surgical

o   Neurolysis is indicated if conservative treatment fails

o   Decompression of the nerve is begun just proximal to the superior extensor retinaculum and extends to the base of the first and second TMT joints

o   Osteophytes can be resected and hypertrophic muscles can be debulked

Approximately 80% of patients have a satisfactory result