Leg Nerve Entrapment Syndromes

by Alparslan Uzun

M.D. Alparslan Uzun· Istanbul Medipol University, School of Medicine, Department of Orthopedics and Traumatology
Apr 25, 2026

     I.         Superficial Peroneal Nerve (SPN)

Definition

·      Compression neuropathy of superficial peroneal nerve

·      Usually seen in transition of the nerve from lateral compartment to anterior ankle

Anatomy

·      SPN is a purely sensory branch

·      Branches from the common peroneal nerve at the level of fibular neck

·      Proceeds distally in the lateral compartment between peroneus longus & brevis

·      It becomes superficial in the distal third of the leg, approximately 12 cm proximal to the tip of lateral malleolus

·      Branches into medial- and intermediate dorsal cutaneous nerves

o   Intermediate dorsal cutaneous nerve: sensation from third, fourth and fifth toes

o   Medial dorsal cutaneous nerve: passes lateral to EHL and provides sensation from the medial aspect of dorsal foot

·      Compression can be seen anywhere along its course

·      Usually posttraumatic – after inversion injuries

·      Iatrogenic injury

o   open management of lateral malleolus fractures

o   placement of anterolateral portal for ankle arthroscopy

Evaluation

·      Burning pain and paresthesias in dorsal foot

·      Pain distribution is similar to L5 dermatome

·      Symptoms are aggrevated by plantar flexion and inversion

·      Tinel sign is usually seen over where the nerve pierces the fascia

·      Motor findings are normal unless more proximal compression

·      Sensory nerve conducting velocities may be prolonged

·      Electrodiagnostic tests are useful for excluding a more proximal cause of compression

·      Diagnosis is usually made based on clinical examination

Imaging

·      Radiographs are helpful for detecting osseous impingement

·      MRI for soft tissue masses

Treatment

·      Non-surgical

o   Injection of local anesthetics and steroids

o   Orthoses to prevent inversion of the ankle

o   Physical therapy to strengthen the muscles around ankle

·      Surgical

o   If the pain doesn’t response to non surgical treatments

o   Should begin at the level at which the nerve exits fascia

o   Neurolysis should proceed distal to the site of compression

o   Fasciotomy is indicated in chronic compartment syndrome

o   80% of patients experience improvement


 

   II.         Sural Nerve

Anatomy

·      Purely sensory nerve that is formed by branches of peroneal and tibial nerves

·      It lies at the midline at the musculotendinous junction of gastrocnemius muscle

·      Descends distally lateral to the Achilles tendon and lies posterior to peroneal tendons

·      Proceeds distally and crosses base of the fifth metatarsal

·      Entrapment can result from fractures of the calcaneus, talus, fifth metatarsal

·      Iatrogenic injury: during ORIF of these fractures and gastrocnemius recession

Evaluation

·      Lateral foot and ankle pain radiating proximally

·      Associated numbness in the same area

·      Positive percussion test typically reproduces paresthesias in the lateral foot

·      Electrophysiological studies are rarely helpful

Imaging

·      Radiographs are helpful for excluding fractures and exostosis

·      MRI for soft tissue masses

Treatment

·      Non-surgical

o   Shoe modification to relieve pressure on the sural nerve

o   Injections can be both diagnostic and therapeutic

·      Surgical

o   Neurolysis is beneficial especially in malreduced fractures

o   In cases of posttraumatic neuroma: excision and burying of proximal stump is recommended

  III.         Saphenous Nerve

·      Provides sensation to the medial ankle and dorsomedial foot

·      Follows greater saphenous vein

·      Can be injured during anteromedial arthroscopic portal placement

·      Saphenous nerve entrapment is rare and usually occur in medial aspect of the knee

·      If a true neuroma present, resection and burying of the proximal stump is recommended because of its subcutaneous location