Morton’s Neuroma

M.D. Alparslan Uzun· Istanbul Medipol University, School of Medicine, Department of Orthopedics and Traumatology
Apr 25, 2026

Definition

·      Compression of interdigital nerve against the distal end of the transvers metatarsal ligament during dorsiflexion of the toes.

·      Generally seen between 3rd and 4th metatarsals

·      Histological examination:

o   perineural fibrosis, degeneration of nerve fibers, endoneural thickening

·      A true neuroma is not present

·      Females are affected more common than males

o   most likely from wearing high heels

·      Deviation of the toe, inflammation of the intermetatarsal bursa, thickening of the transvers metatarsal ligament and forefoot trauma are other precipitating factors.

Evaluation

·      Diagnosis is made by history and physical examination

·      A burning pain just distal to and between metatarsal heads is characteristic

·      Symptoms are aggrevated by activity or by wearing high heel shoes, and relieves immediately after removing the shoes

·      The Mulder sign is elicited by squeezing the foot while palpating the web space.

A painful click is diagnostic of Morton’s Neuroma

·      Neuromas are rare in 1st and 4th web spaces

o   so if there is pain  MTP joint instability?

 

Imaging

·      X-Rays are useful for excluding a stress fracture of the metatarsal neck

·      MRI may be useful, and iv contrast administration increases its accuracy

·      Local anesthetic injection of the involved web space that results in relief is diagnostic

Treatment

·      Non-Surgical

o   Shoe modification : lower heel, wider toe box, metatarsal pad

o   Corticosteroid injections provide temporary relief

o   In 60% of patients, they result in permanent relief

o   Repeated injections may cause MTP joint instability

o   A randomized prospective study showed local anesthetic alone provided equivalent symptom relief compared to combination of local anesthetic and corticosteroid at 3- and 6- months follow ups

·      Surgical

o   Indicated for patients who did not respond to conservative options

o   Dorsal incision are used for primary cases

§  Transverse metatarsal ligament is cut

§  Digital nerve is disected 2-3 cm from intermetatarsal ligament

§  Success rate: 80% / Main complication: incomplete resection

o   Plantar incision are used for recurrent Morton’s Neuromas

§  Transvers metatarsal ligament is preserved

§  Main complication: painful, hypertrophic scars

o   Decompression of interdigital nerve without neuroma resection has been used